The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake

نویسندگان

  • Carly E. Herbison
  • Ketil Thorstensen
  • Anita CG Chua
  • Ross M. Graham
  • John K Olynyk
  • Debbie Trinder
چکیده

1 in human hepatoma cells. 2 3 Carly E. Herbison, Ketil Thorstensen, Anita CG Chua, Ross M. Graham, Peter 4 Leedman, John K Olynyk and Debbie Trinder 5 6 School of Medicine and Pharmacology, The University of Western Australia, Fremantle Hospital, 7 Fremantle, Western Australia, Western Australian Institute for Medical Research, Nedlands, 8 Western Australia, Department of Medical Biochemistry, The Norwegian University of Science and 9 Technology, St. Olavs Hospital, Trondheim, Norway, Laboratory of Cancer Medicine, UWA 10 Centre for Medical Research, Royal Perth Hospital, Perth, Western Australia. 11 12 13 Running Head: TFR1 and TFR2 in hepatoma cells 14 15 16 Address correspondence to: Professor Debbie Trinder, School of Medicine and Pharmacology, The 17 University of Western Australia, Fremantle Hospital, PO Box 480 Fremantle WA 6959, Australia, 18 Tel. +6189431 3640 Fax. +618-9431 2977; Email: [email protected] 19 20 Articles in PresS. Am J Physiol Cell Physiol (October 14, 2009). doi:10.1152/ajpcell.00649.2008

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Transferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.

BACKGROUND/AIMS Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport. It is sensitive to high levels of diferric transferrin, which is associated with disorders of iron overload. Also present in these disorders are increased levels of plasma non-transferrin-bound iron. This study sought to clarify the role of transferrin receptor 2...

متن کامل

The role of transferrin receptor 1 and 2 in transferrin-bound iron uptake in human hepatoma cells.

Transferrin receptor (TFR) 1 and 2 are expressed in the liver; TFR1 levels are regulated by cellular iron levels while TFR2 levels are regulated by transferrin saturation. The aims of this study were to 1) determine the relative importance of TFR1 and TFR2 in transferrin-bound iron (TBI) uptake by HuH7 human hepatoma cells and 2) characterize the role of metal-transferrin complexes in the regul...

متن کامل

The role of Hfe in transferrin-bound iron uptake by hepatocytes.

UNLABELLED HFE-related hereditary hemochromatosis results in hepatic iron overload. Hepatocytes acquire transferrin-bound iron via transferrin receptor (Tfr) 1 and Tfr1-independent pathways (possibly Tfr2-mediated). In this study, the role of Hfe in the regulation of hepatic transferrin-bound iron uptake by these pathways was investigated using Hfe knockout mice. Iron and transferrin uptake by ...

متن کامل

Heterotypic interactions between transferrin receptor and transferrin receptor 2.

Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism. TfR2 is capable of Tf-mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis...

متن کامل

Amines as inhibitors of iron transport in rabbit reticulocytes.

The effect of the known inhibitors of iron uptake, n-butylamine and NH4Cl, was examined at the molecular level to more precisely define the mechanisms by which these lysosomotropic agents block iron uptake by rabbit reticulocytes. Utilizing a rapid pulse-chase technique to follow the handling of a cohort of 59Fe, 125I-transferrin bound to rabbit reticulocytes, both amines were observed to have ...

متن کامل

Treatment of PC12 cells with nerve growth factor increases iron uptake.

Phaeochromocytoma PC12 cells treated with nerve growth factor (NGF) differentiate into a neuronal phenotype. Here we compare the uptake of transferrin-bound and non-transferrin-bound iron in NGF-treated (neuronal phenotype) and control (proliferating) PC12 cells. The non-transferrin-bound iron uptake was greater in the NGF-treated cells than in the control, independently of the uptake time, the...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009